Glo SB Sachet
Composition
| Lyophilized Saccharomyces boulardii: | 5 Billion (equivalent to 250 mg of yeast Saccharomyces boulardii) |
| Excipients: | q.s. |
Pharmacodynamics
Saccharomyces boulardii acts by inhibiting the pathogenic effects of certain micro-organism and/or their toxins, especially Clostridium difficile, the principle causative organism in antibiotic-associated diarrhoea, and Vibrio cholerae, typical of the toxin-producing bacterium responsible for secretory diarrhoea.
Saccharomyces boulardii exerts a trophic and immunostimulant effects on the intestinal tract involving notable and significant increase in the total and specific activity of the intestinal disaccharidases (sucrase, maltase and lactase), and marked increase in secretory IgA concentrations in the intestinal fluid.
Pharmacokinetics
Saccharomyces boulardii, after repeated oral doses, transits in the digestive tract without colonizing it, rapidly attaining significant intestinal concentrations, which are maintained at a constant level throughout the administration period. The cells are spread throughout the small and large intestines, creating a barrier in the gut against bad bacteria. Saccharomyces boulardii is not present in the stools 2-5 days after discontinuation of treatment.
Indications
- Treatment of acute infectious diarrhoea in adults and children
- Prevention and treatment of antibiotics-associated colitis and diarrhoea
- As an addition to vancomycin/metronidazole-treatment to prevent the recurrence of Clostridium difficile diseases
Dosage and Administration
One to two sachets to be given twice daily or as directed by the physician
Glo SB powder should be administered orally, directly or mixed with water (5-10 ml) or a beverage, or in a baby’s feeding bottle. The contents of the sachet should not be mixed in very cold or hot liquids or food.
Contraindications
In patients with a known hypersensitivity to any of the ingredients of the formulation or yeast allergy.
Warnings and Precautions
General
Glo SB powder contains living cells and, therefore, it should not be mixed with very hot (over 50?C), iced or alcoholic drinks or food.
The treatment with Saccharomyces boulardii does not replace rehydration. The patient should be appropriately rehydrated based on the severity of diarrhoea, age and the state of health of the patient.
Drug Interactions
Pregnancy
The safety and efficacy have not been established in pregnant women.
Lactation
The safety and efficacy have not been established in nursing mothers.
Storage and Handling Instructions
Glo SB powder should be stored below 30°C and protected from light.
Packaging Information
Glo SB powder is available as 0.84 g sachet
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