• Covid pandemic has resulted in in a global public health crisis.
• Our awareness about the protective factors of Covid infection is limited
• Hence, preventive healthcare has gained increased importance in preventing the spread of infectious diseases

• Vitamin C is one of the strongest water-soluble anti-oxidant and also the best Natural Immunity Booster
• Vitamin C is such a vitamin that it cannot be produced in our body and therefore, needs to be taken through dietary sources
• Vitamin C plays as a cofactor in many biological processes like the hydroxylation of proline to hydroxyproline.
• In case of Vitamin C deficiency, the formation of collagen is, therefore, impaired.
• Vitamin C has important role in the hydroxylation of dopamine to noradrenaline as well as in steroid synthesis in the adrenal glands
• Vitamin C acts as an electron donor in the conversion of folic acid to tetrahydrofolic acid, and therefore, is indirectly involved in the synthesis of purine and thymine.
• For incorporating Iron into ferritin, Vitamin C is necessary
• Vitamin C has anti-inflammatory activity and it promotes wound healing and also enhances the phagocytic action of leucocytes
• Deficiency can produce scurvy – swollen inflamed gums, hemorrhages and subcutaneous bruising.
• Deficiency of Vitamin D leads to deficiency in the supportive components of bone, collagen and cartilage, making bones to fragile easily and loose teeth
• Anemia commonly occurs, probably due to vitamin C’s role in iron metabolism.

Role of Vitamin C in Covid Prophylaxis

• When Vitamin C is used in early phase in severe acute respiratory syndrome like corona virus infection, it was beneficial
• Cytokine storm involving interleukin-6 and endothelin-1 release leads to severe forms of coronavirus disease
• Vitamin C has been shown to reduce mediators such as interleukin-6 and endothelin-1.
• Severe late-stage coronavirus disease patients may also get benefitted by Vitamin C supplementation

• Vitamin D is naturally present in very few foods and is a fat-soluble vitamin
• Our skin produces Vitamin D when Ultraviolet rays from sunlight falls on the skin
• Vitamin D synthesized from sun exposure, taken through food, and supplements is biologically not active and must undergo two hydroxylation reactions in the body for activation
• The first conversion occurs in our liver and vitamin D is converted in to 25-hydroxyvitamin D [25(OH)D], which also called calcidiol.
• The second conversion happens in our kidney and leads to formation of physiologically active 1,25-dihydroxyvitamin D [1,25(OH)2D], also called calcitriol

Role of Vitamin D in Bone Metabolism

• Vitamin D is essential for the calcium absorption in the gastro-intestinal tract and Vitamin D helps maintain adequate plasma calcium and phosphate levels to enable normal mineralization of bone and to stop hypocalcemic effect known as tetany.
• Vitamin D is also required for bone growth and bone remodeling by bone cells osteoblasts and osteoclasts
• Low vitamin D may lead to thin bones, brittle bones, or sometimes fractures.
• It is shown that adequate Vitamin D levels prevent rickets in children and osteomalacia in adults.
• Vitamin D along with calcium helps protect aged people from osteoporosis.
• Vitamin D has many roles in the body, including intonation of cell growth, neuromuscular and immune function, and reduction of inflammation.
• Vitamin D modulates in part many genes encoding proteins that regulate cell differentiation, proliferation and programmed cell death

Role of Vitamin D in Protective Immunity

Normal plasma level of Vitamin D is >30 ng/mL levels whereas Vitamin D levels between 29 and 21 ng/mL were considered as insufficient, and levels < 20 ng/mL is considered as deficient

• Since early 19 th century, Vitamin D has been used to treat infections such as tuberculosis even before the discovery of effective antibiotics
• Tuberculosis patients were exposed to sunlight in sanatoriums that was thought to directly destroy the tuberculosis.
• Cod liver oil was used treat tuberculosis and for general increased protection from infections and later on it was found that cod liver oil is actually a rich source of vitamin D

Role of Vitamin D in Reducing Risk of Complications of Covid-19

• Many studies have proven the role of vitamin D in lowering the risk of acute viral respiratory tract infections as well as pneumonia.
• It was demonstrated to directly inhibit viral replication or have anti-inflammatory action or immunomodulatory action
• In many trials, vitamin D supplementation was shown to be safe and effective against acute respiratory tract infectious diseases
• People having lower levels of Vitamin D were shown to be at higher risk this global pandemic and Vitamin Supplementation should be considered to increase the circulating 25(OH)D to the optimal levels (75–125 nmol/L).

• Impaired smell and taste, fever, cough, sore throat, general weakness, pain as aching limbs, runny nose, and in some cases, diarrhea are observed as most common symptoms in COVID-19 infection
• Most of these symptoms are associate with altered zinc homeostasis and explain how zinc might prevent or attenuate those symptoms
• In Covid-19 patients, Zinc is shown to be very promising agent

Role of Zinc in Protection from Viral Infections

• Tissue barriers equipped with cilia and mucus, antimicrobial peptides like lysozymes and interferons which are affected by Zinc, prevent entry of microorganisms into the human body
• The angiotensin-converting enzyme 2 (ACE2) and the cellular protease TMPRSS2 are the two major mechanisms by which Covid virus enters our cells
• Zinc helps in muco-ciliary clearance of viruses
• Tissue barriers are affectively preserved by Zinc
• Viral entry into our body is affected by Zinc-dependent alterations in gene expression by pneumocytes

• Amla is well known as immunity booster since ancient times and has been widely used to prevent infections, much before the discovery of modern medicines and vaccines.
• As per Ayurveda, Amla helps balance the three Doshas in our body and can help eliminate virus and bacteria that are the underlying cause of most ailments.
• Amla is rich in Vitamin C compared to an orange, almost eight times and pomegranate, almost seventeen times

Role of Amla in Covid

• There is a loss of smell and taste in Covid infection and Amla is very effective in stimulating the smell and taste buds

1 Tablet, twice a day

Presented in a strip of 10 Chewable Orange Flavoured Tablets